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Random folders are created with single sub folder amd64 in D drive in many of my Clint PC within the domain after SCCM agent installed.
Please try to solve this issue.
These folders are created by Software Update and it is the SU they are not cleaning up after themselves. There isn't a lot that you can do about them but deleted them. BUT make sure that you have rebooted the computer after you have applied the SU.
Yh. After i removed the application deployment from the SCCM it seems running fine now.
Generated folders deleted and in some PCs after restart those folders removed already.